Título

Mycobacterium tuberculosis TLR2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcription

Autor

ERIKA NAHOMY MARINO MARMOLEJO

CITLALLI TORNEZ BENITEZ

VANIA ELVIRA BONIFAZ PENA

MABEL GUZMAN RODRIGUEZ

HUGO ENRIQUE LOPEZ GONZALEZ

ABEL GUTIERREZ ORTEGA

MARTHA LETICIA SANTOS MARTINEZ

MARIO ALBERTO FLORES VALDEZ

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Identificador alterno

doi: http://dx.doi.org/10.5897/AJMR11.415

Materias

Mycobacterium tuberculosis - (AUTOR) Toll-like receptor 2 (TLR2) - (AUTOR) Notch1 - (AUTOR) Socs3 - (AUTOR) Innate immunity - (AUTOR) BIOLOGÍA Y QUÍMICA - (CTI)

Resumen o descripción

"Mycobacterium tuberculosis employs a number of strategies to subvert host signaling events, leading to its persistence within macrophages. Upon infection, Mycobacterium bovis BCG induce the expression of suppressor of cytokine signaling 3 (socs3), in a Toll-like receptor 2 (TLR2)-Notch1-dependent manner. Purified phosphatidyl inositol di-mannosides (a TLR2 agonist) act as an inducer for the Notch1-socs3 pathway. This prompted us to analyze other TLR2 agonists seeking for additional molecules that may affect this pathway. We found that lipoprotein LprA, as well as glycolipids lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM) treatment of murine macrophages resulted in stimulation of notch1 and socs3 transcription."

Editor

Academic Journals

Fecha de publicación

agosto de 2011

Tipo de publicación

Artículo

Versión de la publicación

Versión publicada

Recurso de información

http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1206

Formato

application/pdf

Idioma

Inglés

Sugerencia de citación

Erika Nahomy Marino-Marmolejo, et al. (2011). Mycobacterium tuberculosis TLR2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcription. African Journal of Microbiology Research 5.15 (2011): 2168-2172. http://dx.doi.org/10.5897/AJMR11.415

Repositorio Orígen

Repositorio IPICYT

Descargas

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