Title

Mycobacterium tuberculosis TLR2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcription

Author

ERIKA NAHOMY MARINO MARMOLEJO

CITLALLI TORNEZ BENITEZ

VANIA ELVIRA BONIFAZ PENA

MABEL GUZMAN RODRIGUEZ

HUGO ENRIQUE LOPEZ GONZALEZ

ABEL GUTIERREZ ORTEGA

MARTHA LETICIA SANTOS MARTINEZ

MARIO ALBERTO FLORES VALDEZ

Access level

Open Access

Alternative identifier

doi: http://dx.doi.org/10.5897/AJMR11.415

Summary or description

"Mycobacterium tuberculosis employs a number of strategies to subvert host signaling events, leading to its persistence within macrophages. Upon infection, Mycobacterium bovis BCG induce the expression of suppressor of cytokine signaling 3 (socs3), in a Toll-like receptor 2 (TLR2)-Notch1-dependent manner. Purified phosphatidyl inositol di-mannosides (a TLR2 agonist) act as an inducer for the Notch1-socs3 pathway. This prompted us to analyze other TLR2 agonists seeking for additional molecules that may affect this pathway. We found that lipoprotein LprA, as well as glycolipids lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM) treatment of murine macrophages resulted in stimulation of notch1 and socs3 transcription."

Publisher

Academic Journals

Publish date

August, 2011

Publication type

Article

Publication version

Published Version

Format

application/pdf

Language

English

Citation suggestion

Erika Nahomy Marino-Marmolejo, et al. (2011). Mycobacterium tuberculosis TLR2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcription. African Journal of Microbiology Research 5.15 (2011): 2168-2172. http://dx.doi.org/10.5897/AJMR11.415

Source repository

Repositorio IPICYT

Downloads

170

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