Título

Synchronization and activation in a model of a network of β-cells

Autor

JUAN GONZALO BARAJAS RAMIREZ

Alejandro Ricardo Femat Flores

Henk Nijmeijer

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Identificador alterno

doi: https://doi.org/10.1016/j.automatica.2011.02.041

Materias

Network synchronization - (AUTOR) β Cells - (AUTOR) Activation - (AUTOR) Coupling - (AUTOR) CIENCIAS FÍSICO MATEMÁTICAS Y CIENCIAS DE LA TIERRA - (CTI) MATEMÁTICAS - (CTI) MATEMÁTICAS - (CTI)

Resumen o descripción

"Islets of pancreatic β-cells are of utmost importance in the understanding of diabetes mellitus. We consider here a model of a network of such pancreatic β-cells which are globally coupled via gap junctions. Some of the cells in the islet produce bursting oscillations while other cells are inactive. We prove that the cells in the islet synchronize if the coupling is sufficiently large and all cells are active (or inactive). If the islet consists of both active and inactive cells and the coupling is sufficiently large, an active cluster and an inactive cluster emerge. We show that activity of the islet depends on the coupling strength and the number of active cells compared to the number of inactive cells. If too few cells are active the islet becomes inactive."

Editor

Elsevier

Fecha de publicación

2011

Tipo de publicación

Artículo

Versión de la publicación

Versión enviada

Recurso de información

http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1705

Formato

application/pdf

Sugerencia de citación

J.G. Barajas-Ramírez, E. Steur, R. Femat, H. Nijmeijer, Synchronization and activation in a model of a network of β-cells, Automatica, Volume 47, Issue 6, 2011, Pages 1243-1248.

Repositorio Orígen

Repositorio IPICYT

Descargas

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