Title
Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice
Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice
Author
ANABELLA MARTINEZ DOMINGUEZ
IRAZU CONTRERAS YANEZ
JOSE ANTONIO ESTRADA GUADARRAMA
Access level
true
Open Access
Subjects
Multidisciplinarias (Ciencias Sociales) - ([Acta Universitaria (México) Num.6 Vol.27]) Oxidative stress - ([Acta Universitaria (México) Num.6 Vol.27]) lipid peroxidation - ([Acta Universitaria (México) Num.6 Vol.27]) iron deficiency - ([Acta Universitaria (México) Num.6 Vol.27]) central nervous system - ([Acta Universitaria (México) Num.6 Vol.27]) spleen - ([Acta Universitaria (México) Num.6 Vol.27]) Multidisciplinarias (Ciencias Sociales) - ([Acta Universitaria (México) Num.6 Vol.27]) Oxidative stress - ([Acta Universitaria (México) Num.6 Vol.27]) lipid peroxidation - ([Acta Universitaria (México) Num.6 Vol.27]) iron deficiency - ([Acta Universitaria (México) Num.6 Vol.27]) central nervous system - ([Acta Universitaria (México) Num.6 Vol.27]) spleen - ([Acta Universitaria (México) Num.6 Vol.27]) CIENCIAS SOCIALES - (CTI)
Summary or description
Oxidative stress (OS) is considered a risk factor for neurodegenerative disorders. Iron concentrations have been related to OS; however, the effect of iron deficiency (ID) on the induction of OS in the central nervous system (CNS) is unknown. A murine model of chronic diet-induced ID using 2 month-old male BALB/c mice (6 specimen), was used to determine its role in OS induction. Lipid peroxidation was determined by measuring thiobarbituric acid-reactive species (TBARS) in the CNS, using the spleen for comparison. A decrease of peroxidation products in the CNS of the ID group (ID CNS), compared to controls fed on a regular diet, was found. The spleen showed a significant increase of lipid peroxidation in the ID group. Our results suggest that chronic ID may have differential effects on OS in the CNS and peripheral tissues. A decreased amount of reactive oxygen species in the basal state may be related to alterations on normal CNS metabolism and functions under chronic ID.
Publisher
Universidad de Guanajuato
Publish date
2017
Publication type
Article
Information Resource
Format
application/application/pdf
Source
Acta Universitaria (México) Num.6 Vol.27
Language
English
Relation
http://www.redalyc.org/revista.oa?id=416
Audience
Students
Researchers
Source repository
REPOSITORIO INSTITUCIONAL DE LA UAEM
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