Título
Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice
Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice
Autor
ANABELLA MARTINEZ DOMINGUEZ
IRAZU CONTRERAS YANEZ
JOSE ANTONIO ESTRADA GUADARRAMA
Nivel de Acceso
true
Acceso Abierto
Materias
Multidisciplinarias (Ciencias Sociales) - ([Acta Universitaria (México) Num.6 Vol.27]) Oxidative stress - ([Acta Universitaria (México) Num.6 Vol.27]) lipid peroxidation - ([Acta Universitaria (México) Num.6 Vol.27]) iron deficiency - ([Acta Universitaria (México) Num.6 Vol.27]) central nervous system - ([Acta Universitaria (México) Num.6 Vol.27]) spleen - ([Acta Universitaria (México) Num.6 Vol.27]) Multidisciplinarias (Ciencias Sociales) - ([Acta Universitaria (México) Num.6 Vol.27]) Oxidative stress - ([Acta Universitaria (México) Num.6 Vol.27]) lipid peroxidation - ([Acta Universitaria (México) Num.6 Vol.27]) iron deficiency - ([Acta Universitaria (México) Num.6 Vol.27]) central nervous system - ([Acta Universitaria (México) Num.6 Vol.27]) spleen - ([Acta Universitaria (México) Num.6 Vol.27]) CIENCIAS SOCIALES - (CTI)
Resumen o descripción
Oxidative stress (OS) is considered a risk factor for neurodegenerative disorders. Iron concentrations have been related to OS; however, the effect of iron deficiency (ID) on the induction of OS in the central nervous system (CNS) is unknown. A murine model of chronic diet-induced ID using 2 month-old male BALB/c mice (6 specimen), was used to determine its role in OS induction. Lipid peroxidation was determined by measuring thiobarbituric acid-reactive species (TBARS) in the CNS, using the spleen for comparison. A decrease of peroxidation products in the CNS of the ID group (ID CNS), compared to controls fed on a regular diet, was found. The spleen showed a significant increase of lipid peroxidation in the ID group. Our results suggest that chronic ID may have differential effects on OS in the CNS and peripheral tissues. A decreased amount of reactive oxygen species in the basal state may be related to alterations on normal CNS metabolism and functions under chronic ID.
Editor
Universidad de Guanajuato
Fecha de publicación
2017
Tipo de publicación
Artículo
Recurso de información
Formato
application/application/pdf
Fuente
Acta Universitaria (México) Num.6 Vol.27
Idioma
Inglés
Relación
http://www.redalyc.org/revista.oa?id=416
Audiencia
Estudiantes
Investigadores
Repositorio Orígen
REPOSITORIO INSTITUCIONAL DE LA UAEM
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