Título
Environmental Nanoparticles Reach Human Fetal Brains
Autor
LILIAN OFELIA CALDERON GARCIDUEÑAS
ANGEL AUGUSTO PEREZ CALATAYUD
ANGELICA GONZALEZ MACIEL
RAFAEL REYNOSO ROBLES
Héctor Gabriel Silva Pereyra
Andrea Ramos Morales
RICARDO TORRES JARDON
Candelario de Jesús Soberanes Cerino
Raúl Carrillo Esper
JESÚS CARLOS BRIONES GARDUÑO
Yazmin del Socorro Conde Gutiérrez
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: https://doi.org/10.3390/biomedicines10020410
Materias
Environmental medicine - (AUTOR) Placental impairment - (AUTOR) Neurodevelopmental disorders - (AUTOR) Fetal brains - (AUTOR) Erythroblasts - (AUTOR) Preeclampsia - (AUTOR) Nanoparticles - (AUTOR) NPs extracellular vesicles - (AUTOR) Petrochemical pollution - (AUTOR) Villahermosa - (AUTOR) Tabasco - (AUTOR) BIOLOGÍA Y QUÍMICA - (CTI) QUÍMICA - (CTI) BIOQUÍMICA - (CTI) BIOQUÍMICA - (CTI)
Resumen o descripción
"Anthropogenic ultrafine particulate matter (UFPM) and industrial and natural nanoparticles (NPs) are ubiquitous. Normal term, preeclamptic, and postconceptional weeks(PCW) 8–15 human placentas and brains from polluted Mexican cities were analyzed by TEM and energy-dispersive X-ray spectroscopy. We documented NPs in maternal erythrocytes, early syncytiotrophoblast, Hofbauer cells, and fetal endothelium (ECs). Fetal ECs exhibited caveolar NP activity and widespread erythroblast contact. Brain ECs displayed micropodial extensions reaching luminal NP-loaded erythroblasts. Neurons and primitive glia displayed nuclear, organelle, and cytoplasmic NPs in both singles and conglomerates. Nanoscale Fe, Ti, and Al alloys, Hg, Cu, Ca, Sn, and Si were detected in placentas and fetal brains. Preeclamptic fetal blood NP vesicles are prospective neonate UFPM exposure biomarkers. NPs are reaching brain tissues at the early developmental PCW 8–15 stage, and NPs in maternal and fetal placental tissue compartments strongly suggests the placental barrier is not limiting the access of environmental NPs. Erythroblasts are the main early NP carriers to fetal tissues. The passage of UFPM/NPs from mothers to fetuses is documented and fingerprinting placental single particle composition could be useful for postnatal risk assessments. Fetal brain combustion and industrial NPs raise medical concerns about prenatal and postnatal health, including neurological and neurodegenerative lifelong consequences."
Editor
MDPI
Fecha de publicación
2022
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Sugerencia de citación
Calderón-Garcidueñas, L.; Pérez-Calatayud, Á.A.; González-Maciel, A.; Reynoso-Robles, R.; Silva-Pereyra, H.G.; Ramos-Morales, A.; Torres-Jardón, R.; Soberanes-Cerino, C.d.J.; Carrillo-Esper, R.; Briones-Garduño, J.C.; Conde-Gutiérrez, Y.d.S. Environmental Nanoparticles Reach Human Fetal Brains. Biomedicines 2022, 10, 410. https://doi.org/10.3390/biomedicines10020410
Repositorio Orígen
Repositorio IPICYT
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