Author: SERGIO RUBEN PERAZA SANCHEZ

Medicinal potions used against infectious bowel diseases in Mayan traditional medicine

SERGIO RUBEN PERAZA SANCHEZ (2010)

Aim of the study: Since one of the main health problems of the indigenous population are infectious bowel

diseases, we decided to test Mayan medicinal potions used to treat these conditions against some of the

causal agents.

Materials and methods: Thirty-one herbal formulations used for the treatment of infectious bowel diseases

were prepared according to the collected ethnobotanical data. Their activities were tested against some

of the causal agents of diarrheic symptoms, such as Entamoeba histolytica, Giardia lamblia, Escherichia coli,

Klebsiella pneumoniae, Salmonella typhi and Shigella flexneri.

Results: Nine formulations were active against bacteria (MIC = 0.5 mg/ml), four on Entamoeba histolytica,

and seven on Giardia lamblia (IC

≤20 g/ml).

Conclusions: This work supports the use of the traditional Mayan formulations against some infectious

bowel diseases, and it is the first step towards their study.

Article

CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA

Antigiardial activity of flavonoids from leaves of Aphelandra scabra

SERGIO RUBEN PERAZA SANCHEZ (2015)

Aphelandra scabra (Vahl) Sm., Acanthaceae, is a shrub widely used by some Mayan communities as carminative, antidote, and remedy for some infections. Bio-guided isolation of the methanol extract of leaves led us to the purification of the anti-giardial metabolites cirsimaritin and sorbifolin, along with the inactive metabolites cirsimarin, sorbifolin-6-O-β-glucopyranoside, and squalene. Cirsimaritin displayed high activity in the anti-giardial bioassay with an IC50 = 3.8 µM, being considered as outstanding when compared to previous reported metabolites, while sorbifolin showed a low activity with an IC50 = 75.6 µM. Additionally, both compounds proved not to be cytotoxic in an in vitro bioassay against HEK-293, a normal cell line. This is the first investigation on anti-giardial properties of A. scabra and its phytochemistry as well, thus the isolated compounds are considered as new for the plant genus and for the species.

Article

ACANTHACEAE ANTI-GIARDIAL ACTIVITY APHELANDRA SCABRA CIRSIMARITIN FLAVONOIDS BIOLOGÍA Y QUÍMICA

Bonediol, a new alkyl catechol from Bonellia macrocarpa

SERGIO RUBEN PERAZA SANCHEZ (2011)

A new alkyl catechol (bonediol) was isolated from root bark of Bonellia macrocarpa. The structure of bonediol was characterized by spectral analysis (UV, IR, 1D and 2D NMR, and MS). Bonediol exhibited certain activity and selectivity on three cancer cell lines (KB, Hep-2, and SiHa).

Article

CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA CIENCIAS AGRARIAS OTRAS ESPECIALIDADES AGRARIAS OTRAS

The Leishmanicidal Effect of (3S)-16,17Didehydrofalcarinol, an Oxylipin Isolated from Tridax procumbens, is Independent of NO Production

SERGIO RUBEN PERAZA SANCHEZ (2010)

The in vitro leishmanicidal effect of (3S)-16,17-didehydrofalcarinol (1) isolated from Tridax procumbens whole

plant against Leishmania mexicana, the causative agent of cutaneous leishmaniasis (chiclero’s ulcer) in the

New World, was investigated. This oxylipin showed signifi cant in vitro activity against promastigotes and intracellular

amastigotes of L.

mexicana.

Its inhibitory effect on amastigotes was not due to activation

of NO in

recombinant

γ-interferon-stimulated

macrophages,

since the production of NO was decreased

in presence

of

the oxylipin. This is the fi rst report on the leishmanicidal activity against the intracellular stage (amastigote) of

the oxylipin (3S)-16,17-didehydrofalcarinol.

Article

CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA

Isolation of ap-hydroxyphenyl anhydride from the leaves of Diphysa carthagenensis

SERGIO RUBEN PERAZA SANCHEZ (2012)

Diphysidione (1), a newp-hydroxyphenyl anhydride, and vitexin (2) were isolated

from the leaves of Diphysa carthagenensis. The structure of the new metabolite

was characterised as 4-(4-hydroxy-phenyl)-3H-pyran-2,6-dione using 1D and 2D

NMR spectroscopy.

Article

CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA

Cytotoxic constituents from the stem bark of Alvaradoa Amorphoides

SERGIO RUBEN PERAZA SANCHEZ (2015)

The chemical study of Alvaradoa amorphoides led to the isolation of four major constituents: chrysophanol (1), β-sitosterol (2), atraric acid (3), and 17-octadecen-6-ynoic acid (4). All compounds were evaluated on in vitro cytotoxic and antiproliferative assays. Atraric acid and 17-octadecen-6-ynoic acid showed cytotoxic activity. Additionally, compound 4 exhibited cytotoxic activity showing a certain degree of selectivity against cancer cell lines. 

Article

ALVARADOA AMORPHOIDES CYTOTOXIC ACTIVITY ANTIPROLIFERATIVE ACTIVITY ACETYLENIC COMPOUND BIOLOGÍA Y QUÍMICA

Screening of Yucatecan plant extracts to control Colletotrichum gloeosporioides and isolation of a new pimarene from Acacia pennatula

SERGIO RUBEN PERAZA SANCHEZ ESAU RUIZ SANCHEZ (2005)

Screening of seven Yucatecan plant extracts to look for fungicidal activity for the control of Colletotrichum gloeosporioides was carried out. Bioassay-directed purification of the root extract of one of the most active plants, Acacia pennatula, resulted in the isolation of the new compound 15,16-dihydroxypimar-8(14)-en-3-one (1), which in the in vitro bioassay "agar dilution" was shown to have growth, sporulation, and germination inhibition activity. Nuclear magnetic resonance spectrascopic techniques were used to elucidate its structure.

Article

 ACACIA PENNATULA COLLETOTRICHUM GLOEOSPORIOIDES DITERPENE PETIVERIA ALLIACEA PIMARENE PISCIDIA PISCIPULA BIOLOGÍA Y QUÍMICA

Phytochemical and pharmacological studies on species of Dorstenia genus (2000-2016)

HECTOR ARTURO PENICHE PAVIA BLANCA MARINA VERA KU SERGIO RUBEN PERAZA SANCHEZ (2018)

The main objective of this review is to update the current knowledge on species of Dorstenia genus. Previous review was published in 2000. This genus includes 117 accepted named species, from which metabolites with a great variety of structures are found. In the last fifteen years, a blooming has occurred in the research of the genus, with more than 60 original research papers on the chemistry and pharmacology of many species, being one of the main reasons to this thriving the generalized use of Dorstenia species in the traditional medicine around the world.

Article

PHYTOCHEMISTRY AND PHARMACOLOGY DORSTENIA COUMARINS TERPENES FLAVONOIDS BIOLOGÍA Y QUÍMICA BIOLOGÍA Y QUÍMICA

Cytotoxic activity of casearborin c isolated from casearia corymbosa

MARIA LEONOR VILA LUNA ROSA ESTHER MOO PUC Luis Wiliunfo Torres Tapia SERGIO RUBEN PERAZA SANCHEZ (2018)

Casearborin c (1), syringic acid (2), ent-3β-hydroxy-(-)-13-epi-manoyl oxide (3), ent-(-)-13-epi-manoyl oxide (4), ent-(-)-kaur-16-en-19-oic acid (5), and γ-sitosterol (6) were isolated from Casearia corymbosa stem bark. Only casearborin c showed cytotoxic activity on HeLa and SiHa cancer cell lines. This work contributes to the description of three compounds (1-3) newly isolated from C. corymbosa and highlights that casearborin c, a clerodane-type diterpene, is responsible for the cytotoxic activity shown in the original methanol extract of this species.

Article

SALICACEAE CASEARIA CORYMBOSA CYTOTOXIC ACTIVITY DITERPENES CLERODANES CASEARBORIN C BIOLOGÍA Y QUÍMICA BIOLOGÍA Y QUÍMICA

Theveridoside, an iridoid glucoside from Thevetia gaumeri

SERGIO RUBEN PERAZA SANCHEZ KARLINA GARCIA SOSA TRINIDAD PLUMA ANGULO PAULINO SIMA POLANCO Luis Manuel Peña-Rodríguez (2001)

The identific.ation of theveridoside (1), an iridoid glucoside isolated from the roots of Thevetia gaumeri is reported. The structure of 1 was established from its spectroscopic data and those of its peracetylated derivative la.

Article

THEVETIA GAUMERI APOCYNACEAE IRIDOID GLUCOSIDE THEVERIDOSIDE BIOLOGÍA Y QUÍMICA BIOLOGÍA Y QUÍMICA