Multi-environment genomic prediction of plant traits using deep learners with dense architecture

Osval Antonio Montesinos-Lopez Jose Crossa (2018, [Artículo])

Shared Data Resources Deep Learning Genomic Prediction CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA ACCURACY GENOMICS NEURAL NETWORKS FORECASTING DATA MARKER-ASSISTED SELECTION

Big data, small explanatory and predictive power: Lessons from random forest modeling of on-farm yield variability and implications for data-driven agronomy

Martin van Ittersum (2023, [Artículo])

Context: Collection and analysis of large volumes of on-farm production data are widely seen as key to understanding yield variability among farmers and improving resource-use efficiency. Objective: The aim of this study was to assess the performance of statistical and machine learning methods to explain and predict crop yield across thousands of farmers’ fields in contrasting farming systems worldwide. Methods: A large database of 10,940 field-year combinations from three countries in different stages of agricultural intensification was analyzed. Random effects models were used to partition crop yield variability and random forest models were used to explain and predict crop yield within a cross-validation scheme with data re-sampling over space and time. Results: Yield variability in relative terms was smallest for wheat and barley in the Netherlands and for wheat in Ethiopia, intermediate for rice in the Philippines, and greatest for maize in Ethiopia. Random forest models comprising a total of 87 variables explained a maximum of 65 % of cereal yield variability in the Netherlands and less than 45 % of cereal yield variability in Ethiopia and in the Philippines. Crop management related variables were important to explain and predict cereal yields in Ethiopia, while predictive (i.e., known before the growing season) climatic variables and explanatory (i.e., known during or after the growing season) climatic variables were most important to explain and predict cereal yield variability in the Philippines and in the Netherlands, respectively. Finally, model cross-validation for regions or years not seen during model training reduced the R2 considerably for most crop x country combinations, while for wheat in the Netherlands this was model dependent. Conclusion: Big data from farmers’ fields is useful to explain on-farm yield variability to some extent, but not to predict it across time and space. Significance: The results call for moderate expectations towards big data and machine learning in agronomic studies, particularly for smallholder farms in the tropics where model performance was poorest independently of the variables considered and the cross-validation scheme used.

Model Accuracy Model Precision Linear Mixed Models CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA MACHINE LEARNING SUSTAINABLE INTENSIFICATION BIG DATA YIELDS MODELS AGRONOMY

A novel method for genomic-enabled prediction of cultivars in new environments

Osval Antonio Montesinos-Lopez Brandon Alejandro Mosqueda González Jose Crossa (2023, [Artículo])

Genomic Best Linear Unbiased Prediction Gains in Accuracy Genomic Prediction Novel Methods CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA GENOTYPE ENVIRONMENT INTERACTION METHODS ENVIRONMENT

Multimodal deep learning methods enhance genomic prediction of wheat breeding

Carolina Rivera-Amado Francisco Pinto Francisco Javier Pinera-Chavez David González-Diéguez Matthew Paul Reynolds Paulino Pérez-Rodríguez Huihui Li Osval Antonio Montesinos-Lopez Jose Crossa (2023, [Artículo])

Conventional Methods Genomic Prediction Accuracy Deep Learning Novel Methods CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA WHEAT BREEDING MACHINE LEARNING METHODS MARKER-ASSISTED SELECTION

A simple extension to the CMASA method for the prediction of catalytic residues in the presence of single point mutations

David Israel Flores Granados (2014, [Artículo])

The automatic identification of catalytic residues still remains an important challenge in structural bioinformatics. Sequence-based methods are good alternatives when the query shares a high percentage of identity with a well-annotated enzyme. However, when the homology is not apparent, which occurs with many structures from the structural genome initiative, structural information should be exploited. A local structural comparison is preferred to a global structural comparison when predicting functional residues. CMASA is a recently proposed method for predicting catalytic residues based on a local structure comparison. The method achieves high accuracy and a high value for the Matthews correlation coefficient. However, point substitutions or a lack of relevant data strongly affect the performance of the method. In the present study, we propose a simple extension to the CMASA method to overcome this difficulty. Extensive computational experiments are shown as proof of concept instances, as well as for a few real cases. The results show that the extension performs well when the catalytic site contains mutated residues or when some residues are missing. The proposed modification could correctly predict the catalytic residues of a mutant thymidylate synthase, 1EVF. It also successfully predicted the catalytic residues for 3HRC despite the lack of information for a relevant side chain atom in the PDB file. © 2014 Flores et al.

1UU9 protein, 3HRC protein, protein, thymidylate synthase, unclassified drug, protein kinase, thymidylate synthase, accuracy, algorithm, Article, CMASA, CMASA Substitution Matrix, Contact Matrix Average Deviation, controlled study, correlation coeffi CIENCIAS FÍSICO MATEMÁTICAS Y CIENCIAS DE LA TIERRA MATEMÁTICAS ANÁLISIS NUMÉRICO ANÁLISIS NUMÉRICO