Genetic structure analysis and identifying key founder inbred lines in diverse elite sub-tropical maize inbred lines

Melaku Gedil Ana Luisa Garcia-Oliveira Nnanna Unachukwu Cesar Petroli Sarah Hearne Abebe Menkir (2023, [Artículo])

Genetic Relationship Desirable Target Traits Parental Selection CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA GENETIC STRUCTURES INBRED LINES MAIZE BREEDING PROGRAMMES

Erratum: Author Correction: Genetic structure analysis and identifying key founder inbred lines in diverse elite sub-tropical maize inbred lines (Scientific reports (2023) 13 1 (11695))

Melaku Gedil Ana Luisa Garcia-Oliveira Nnanna Unachukwu Cesar Petroli Sarah Hearne Abebe Menkir (2023, [Artículo])

Genetic Relationships Desirable Traits CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA GENETIC STRUCTURES INBRED LINES MAIZE BREEDING PROGRAMMES

Genotyping by sequencing advancements in barley

Naeela Qureshi Mohammad Pourkheirandish (2022, [Artículo])

Genotyping by Sequencing Target Enrichment CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA BARLEY GENOTYPING RESTRICTION ENZYMES SINGLE NUCLEOTIDE POLYMORPHISM

Author Correction: genome-wide association analyses of agronomic traits and Striga hermonthica resistance in pearl millet

Hussein Shimelis Chris Ojiewo Abhishek Rathore (2023, [Artículo])

Agronomic Traits CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA GENOME-WIDE ASSOCIATION STUDIES STRIGA HERMONTHICA PEARL MILLET

Remote sensing of quality traits in cereal and arable production systems: A review

Zhenhai  Li xiuliang jin Gerald Blasch James Taylor (2024, [Artículo])

Cereal is an essential source of calories and protein for the global population. Accurately predicting cereal quality before harvest is highly desirable in order to optimise management for farmers, grading harvest and categorised storage for enterprises, future trading prices, and policy planning. The use of remote sensing data with extensive spatial coverage demonstrates some potential in predicting crop quality traits. Many studies have also proposed models and methods for predicting such traits based on multi-platform remote sensing data. In this paper, the key quality traits that are of interest to producers and consumers are introduced. The literature related to grain quality prediction was analyzed in detail, and a review was conducted on remote sensing platforms, commonly used methods, potential gaps, and future trends in crop quality prediction. This review recommends new research directions that go beyond the traditional methods and discusses grain quality retrieval and the associated challenges from the perspective of remote sensing data.

Quality Traits Grain Protein CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA REMOTE SENSING QUALITY GRAIN PROTEINS CEREALS PRODUCTION SYSTEMS

Partial least squares enhance multi-trait genomic prediction of potato cultivars in new environments

Rodomiro Ortiz Paulino Pérez-Rodríguez Osval Antonio Montesinos-Lopez Jose Crossa (2023, [Artículo])

Potato Traits Cross-Validation Breeding Data CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA LEAST SQUARES METHOD POTATOES ENVIRONMENT PLANT BREEDING

Agro-morphological characterization and estimation of genetic parameters of spring maize hybrids in the inner plains of Far-West Nepal

Sandesh Thapa Darbin Joshi (2022, [Artículo])

Heat Resilient Maize Phenotypic Coefficient of Variation Heritable Traits CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA GENETIC PARAMETERS MAIZE HYBRIDS

QTL cluster analysis and marker development for kernel traits based on DArT markers in spring bread wheat (Triticum aestivum L.)

CAIXIA LAN Ravi Singh (2023, [Artículo])

QTL mapping Kernel-Related Traits Putative Candidate Gene KASP Markers CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA KERNELS QUANTITATIVE TRAIT LOCI MAPPING TRITICUM AESTIVUM SINGLE NUCLEOTIDE POLYMORPHISM

Mapping QTL for phenological and grain-related traits in a mapping population derived from high-zinc-biofortified wheat

Gopalareddy Krishnappa Govindan Velu (2023, [Artículo])

DArT-Seq Gene Mapping Yield Component Traits CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA WHEAT QUANTITATIVE TRAIT LOCI CANDIDATE GENES QUANTITATIVE TRAIT LOCI MAPPING YIELD COMPONENTS BIOFORTIFICATION

Evaluación de la acumulación mitocondrial de estrógenos sintéticos mito-dirigidos en un modelo in vitro

Evaluation of mitochondrial accumulation of mito-targeted synthetic estrogens on in vitro model

Magdiel Orozco Valdivia (2023, [Tesis de maestría])

La mitocondria es un organelo que cumple funciones esenciales en el mantenimiento de las células eucariotas y su disfunción está asociada a la progresión de enfermedades neurodegenerativas, metabólicas y cardiovasculares. Por lo anterior es necesario encontrar tratamientos que mejoren la función mitocondrial. Los estrógenos son hormonas que tienen diversos efectos benéficos sobre las células. Entre estos efectos, se ha observado que las hormonas inciden en la función mitocondrial, por lo que son un potencial tratamiento para las enfermedades asociadas a la disfunción mitocondrial. Una alternativa es mediante los compuestos mito-dirigidos, moléculas con actividad biológica que son acoplados a cationes lipofílicos con la capacidad de acumularse a mayor concentración en la mitocondria respecto a las sustancias no mito-dirigidas. Por lo tanto, se plantea conferir la propiedad acumulativa a los estrógenos mediante el acoplamiento de trifenilfosfonio, un catión lipofílico recurrentemente usado para la generación de mito-dirigidos. Para el presente trabajo se sintetizaron dos estrógenos mito-dirigidos. Este proyecto evalúa la acumulación mitocondrial de los estrógenos mito-dirigidos después de una exposición de estos en un modelo in vitro sensible a estrógenos, comparando su acumulación con la del estrógeno no mito-dirigido. Los resultados indican que los estrógenos mito-dirigidos se acumulan más en las mitocondrias que el estrógeno no mito-dirigido y demuestra que los estrógenos mito-dirigidos tienen capacidad acumulativa, esto permite sentar las bases de un tratamiento hormonal dirigido a las mitocondrias que se pueda aplicar a enfermedades asociadas a la disfunción mitocondrial.

Mitochondria are essential organelles of eukaryotic cells, and their dysfunction is associated with the onset and development of neurodegenerative, metabolic, and cardiovascular diseases. Thus, it is important to develop treatments to improve mitochondrial function. One of the options are estrogens, these hormones have a protective role in cellular function by participating in the regulation of mitochondrial function, making estrogens candidates to be a potential treatment for diseases related to mitochondrial dysfunction. One of the alternative treatments are mito-targeted molecules, which are biologically active molecules conjugated with lipophilic cations. These mito-targeted molecules can accumulate inside mitochondria more than non-targeted molecules. This project aims to synthesize mito-targeted estrogens by conjugating a lipophilic cation, triphenylphosphonium, to a parent estrogenic compound. Our hypothesis is that these novel molecules will accumulate in the interior of the mitochondria and will have more biological activity than the non-targeted estrogen. We synthesized two mito-targeted estrogens for this project and evaluated the mitochondrial accumulation in an estrogen-sensitive in vitro model, comparing their accumulation to non-targeted estrogens. The results indicate mito-targeted estrogens accumulate in mitochondria more than the non-targeted estrogens, showing that mito-targeted estrogens have an accumulation capacity. This insight will make new treatments for diseases related to mitochondrial dysfunction.

estrógenos, mito-dirigido, disfunción mitocondrial, acumulación, mitocondria estrogens, mitochondria, mito-targeted, accumulation, mitochondrial dysfunction BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA HUMANA HORMONAS HORMONAS